TRAFAX is a poorly absorbed oral antibiotic used to treat Irritable Bowel Syndrome with diarrhea, Travelers’ diarrhea and Hepatic Encephalopathy. Trafax has low incidence of drug resistance and has a highly favorable safety profile.
- Rifaximin…………………………………200 MG
Dose: As Directed by the Physician.
Storage: Keep Out of Reach of Children.
Manufactured By: Quest Pharmaceuticals, Nepal
Trafax 200-mg tablets are used to treat traveler’s diarrhea caused by certain bacteria in adults and children at least 12 years of age. Rifaximin 550-mg tablets are used to prevent episodes of hepatic encephalopathy (changes in thinking, behavior, and personality caused by a build-up of toxins in the brain in people who have liver disease) in adults who have liver disease and to treat irritable bowel syndrome (with diarrhea) in adults. Rifaximin is in a class of medications called antibiotics. Rifaximin treats traveler’s diarrhea and irritable bowel syndrome by stopping the growth of the bacteria that cause diarrhea. Rifaximin treats hepatic encephalopathy by stopping the growth of bacteria that produce toxins and that may worsen liver disease. Rifaximin will not work to treat traveler’s diarrhea that is bloody or occurs with a fever.
Antibiotics such as rifaximin will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Direction for Use
Rifaximin comes as a tablet to take by mouth with or without food. When rifaximin is used to treat traveler’s diarrhea, it is usually taken three times a day for 3 days. When rifaximin is used to prevent episodes of hepatic encephalopathy, it is usually taken twice a day. When rifaximin is used to treat irritable bowel syndrome, it is usually taken three times a day for 14 days. To help you remember to take rifaximin, take it around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take rifaximin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are taking rifaximin to treat traveler’s diarrhea, your symptoms should improve within 24 to 48 hours after you start taking the medication. If your symptoms do not go away or they get worse, or if you develop a fever or bloody diarrhea, call your doctor.
If you are taking rifamaxin to treat irritable bowel syndrome and your symptoms return after you have finished your treatment, call your doctor.
Take rifaximin as directed, even if you feel better. If you are taking rifaximin to treat traveler’s diarrhea or irritable bowel syndrome and you stop taking it too soon or if you skip doses, your infection may not be completely cured and the bacteria may become resistant to antibiotics. If you are taking rifaximin to prevent hepatic encephalopathy, do not stop taking it without talking to your doctor as you may experience symptoms of encephalopathy.
Mechanism of Action
Rifaximin is a poorly absorbed bactericidal rifamycin derivative, which inhibits bacterial protein synthesis by irreversibly binding to RpoB, the beta-subunit of the bacterial DNA-dependent RNA polymerase (3).
- stomach pain
- excessive tiredness
- muscle tightening
- joint pain